Description
Product Characteristics:
Aliases: EPK 2 antibody, EPK2 antibody, KPCD3_HUMAN antibody, nPKC nu antibody, nPKC-nu antibody, nPKCnu antibody, nu antibody, PKCnu antibody, PKD 3 antibody, PKD3 antibody, PRK D3 antibody, PRKCN antibody, PRKD 3 antibody, Prkd3 antibody, Protein kinase C antibody, Protein kinase C nu antibody, Protein kinase C nu type antibody, Protein kinase D3 antibody, Protein kinase EPK 2 antibody, Protein kinase EPK2 antibody, Serine threonine protein kinase antibody, Serine/threonine protein kinase D3 antibody, Serine/threonine-protein kinase D3 antibody
Target Information: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]